I have found many, many, MANY! idiosyncrasies with Internet Explorer 64-bit and Sharepoint 2010. Here is one that I had not yet encountered but was easily worked around.
When trying to import a spreadsheet as a list in SharePoint 2010 (Site Actions > View All Site Content > Create > Import Spreadsheet) you will receive the following error in Internet Explorer if you are using the 64-bit version.
This Feature requires Microsoft Internet Explorer version 5.0 or later, and Windows 95 or later.
Considering I haven’t used either of these products in probably 10 years, I figured this was yet another problem with IE 64…
The fix is simple enough… Use the 32-bit version. It will work fine.
At some point I will add in other small details that do not work with SharePoint in IE 64 and list as many as I can find.